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St. John’s wort also has the potential to interact with prescription medication in undesired ways. One study, for example, described a number of cases of serious side effects in patients who were taking St. John’s wort in addition to normal antidepressants ( 7 ). Negut I, Grumezescu V, Grumezescu AM. Treatment strategies for infected wounds. Molecules. 2018;23(9):2392. doi:10.3390/molecules23092392 While it does have the potential for side effects and for interactions with other medications, it also has a robust base of research supporting its use as a treatment for depression. Beyond this, it’s also been studied as an anti-inflammatory and as a treatment for chronic fatigue. Related Articles Hubner W-D, Kirste T. Experience with St John's wort ( Hypericum perforatum) in children under 12 years with symptoms of depression and psychovegetative disturbances. Phytother Res. 2001;15:367-370.
St. John's wort may affect fertility (your ability to have children). You should not use this product if you are trying to get pregnant. Don't combine St John's wort and prescription antidepressants such as SSRIs. That can cause a problem of too much serotonin, called serotonin syndrome. You may have to wait a period of time before you start St. John's wort even if you and your doctor decide to stop taking an antidepressant. (Don't stop taking an antidepressant on your own.) Sarrell EM, Mandelberg A, Cohen HA. Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media. Arch Pediatr Adolesc Med. 2001;155:796-799. Some studies have split the dosage into two or three separate capsules taken at different times of day, while others have not—there’s no clear advantage to one strategy or the other on this front. FAQ Mischoulon D. Update and critique of natural remedies as antidepressant treatments. Psychiatr Clin North Am. 2007;30:51-68.
This medication makes your skin more sensitive to sunlight. St. John's wort also increases skin sensitivity to light. Together, they may have a dangerous impact on skin sensitivity to the sun. Reserpine Data from a 2003 study done in Spain indicates that hyperforin, a derivative found in St. John’s wort, is a compound that interferes with key events in angiogenesis — the formation and growth of cells. This confirms the recent and growing evidence about a potential role of this compound in cancer and metastasis inhibition and makes it a promising drug for further evaluation in the treatment of angiogenesis-related pathologies. 7. May Support Smoking Cessation Severe allergic reaction: Avoid using St. John’s wort if you have a known allergy to it or its ingredients. Ask your pharmacist or healthcare provider for a complete list of the ingredients if you need clarification.
It should not be taken together with foods that contain tyramine i.e. cheese, red wine, preserved meats and yeast extracts. This is due to a MAO inhibition effect. Why is it called St John’s Wort? Generally, the blooming period of Hypericum Perforatum blooms in the monsoon season amidst the St John Baptist’s birth anniversary. Hence, the flowering herb has acquired this name ‘St John’s.’ Likewise, Wort represents “plant.” Taking a large amount of St. John’s Wort has also been associated with Serotonin Syndrome. Serotonin is a chemical in our brain that is associated with mood, hunger, and other bodily functions. The symptoms of the syndrome include hallucinations, nausea, loss of muscle coordination, confusion, and sweating. Legality
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St. John's wort may speed up the breakdown of Xanax in the body, making it less effective. Theophylline St. John's wort is also available as a liquid extract or tea. Ask your doctor to help you find the right dose. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: Rotblatt M, Ziment I. Evidence-Based Herbal Medicine. Philadelphia, Penn:Hanley & Belfus, Inc. 2002:315-321.
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